litaba

Hona joale, litšoantšo tsa magnetic resonance (MRI) li ntse li tsoela pele ho tloha ho litšoantšo tse tloaelehileng tsa sebopeho le litšoantšo tse sebetsang ho ea ho litšoantšo tsa limolek'hule. Multi-nuclear MR E ka fumana tlhahisoleseding e fapaneng ea metabolite 'meleng oa motho, ha e ntse e boloka qeto ea sebaka, ea ntlafatsa ho khetheha ha ho fumanoa mekhoa ea physiological le pathological,' me hona joale ke eona feela theknoloji e ka khonang ho etsa tlhahlobo e sa tsitsang ea palo ea metabolism ea motho ea matla a molek'hule ka vivo.

Ka ho teba ha Lipatlisiso tsa MR tse ngata, e na le menyetla e pharaletseng ea ts'ebeliso ea tlhahlobo ea pele le tlhahlobo ea lihlahala, mafu a pelo, mafu a neurodegenerative, endocrine system, tsamaiso ea tšilo ea lijo le mafu a tsamaiso ea ho hema, le tlhahlobo e potlakileng ea ts'ebetso ea kalafo. Sethala sa morao-rao sa lipatlisiso tsa bongaka sa Philips se tla thusa ho nahana le lingaka tsa bongaka ho etsa lipatlisiso tsa bongaka tse tsoetseng pele. Dr. Sun Peng le Dr. Wang Jiazheng ba tsoang Lefapheng la Tšehetso ea Tleliniki le Theknoloji ea Philips ba fane ka kenyelletso e qaqileng ho nts'etsopele ea mekhoa e mengata ea NMR le tataiso ea lipatlisiso tsa Philips 'MR Platform e ncha ea li-multi-core MR.

Magnetic resonance e hapile Khau ea Nobel ka makhetlo a mahlano nalaneng ea eona, mafapheng a fisiks, k'hemistri, baeloji le bongaka, 'me e fihletse katleho e kholo metheong ea mantlha ea fisiks, sebopeho sa limolek'hule tsa tlhaho, matla a sebopeho sa macromolecular ea biological, le litšoantšo tsa bongaka tsa bongaka. Har'a tsona, litšoantšo tsa magnetic resonance li fetohile e 'ngoe ea mekhoa ea bohlokoa ka ho fetisisa ea litsebi tsa bongaka, e sebelisoang haholo ho hlahloba mafu a sa tšoaneng likarolong tse sa tšoaneng tsa' mele oa motho. Ka ntlafatso e tsoelang pele ea litlhoko tsa tlhokomelo ea bophelo bo botle, tlhokahalo e kholo ea tlhahlobo ea pele le tlhahlobo ea ts'ebetso e potlakileng e khothalletsa nts'etsopele ea litšoantšo tsa magnetic resonance ho tloha litšoantšong tsa mekhoa ea setso (T1w, T2w, PDw, joalo-joalo), litšoantšo tse sebetsang (DWI, PWI, joalo-joalo) ho litšoantšo tsa limolek'hule (1H MRS Le li-multi-core MRS / MRI).

Semelo se rarahaneng sa 1H e thehiloeng MR Technology, ponahalo e fetang, le khatello ea metsi / mafura e fokotsa sebaka sa eona e le theknoloji ea litšoantšo tsa limolek'hule. Ke palo e lekanyelitsoeng feela ea limolek'hule (choline, creatine, NAA, joalo-joalo) e ka fumanoang, 'me ho thata ho fumana mekhoa e matla ea metabolism ea molek'hule. E ipapisitse le mefuta e fapaneng ea li-nuclide (23Na, 31P, 13C, 129Xe, 17O, 7Li, 19F, 3H, 2H), MR ea nyutlelie e mengata e ka fumana tlhaiso-leseling e fapaneng ea metabolism ea 'mele oa motho, e nang le qeto e phahameng le e ikhethang e phahameng,' me hajoale ke eona feela e sa hlaseheng, e sa tsitsang, e sa tsitsang ea li-radioactivity; (tsoekere, li-amino acid, li-fatty acids - tse seng chefo) bakeng sa tlhahlobo ea bongata ba lits'ebetso tsa metabolism ea limolek'hule tsa motho.

Ka tsoelo-pele e tsoelang pele tsamaisong ea hardware ea magnetic resonance, mokhoa oa ho latellana ka potlako (Multi-Band, Spiral) le acceleration algorithm (compressed sensing, deep learning), multi-core MR Imaging / spectroscopy butle-butle e ntse e hōla butle-butle: (1) ho lebeletsoe hore e be sesebelisoa sa bohlokoa bakeng sa lipatlisiso tsa biology ea molek'hule, biochemistry le metabolism ea batho; (2) Ha e ntse e tloha lipatlisisong tsa saense ho ea litsing tsa kliniki (liteko tse ngata tsa kliniki tse thehiloeng ho MR tse ngata tsa mantlha li ntse li tsoela pele, FIG. 1), e na le menyetla e pharaletseng ea ho hlahloba pele le ho hlahlojoa ha kankere, lefu la pelo, neurodegenerative, mafu a tšilo ea lijo le ho phefumoloha, le tlhahlobo e potlakileng ea katleho.

Ka lebaka la melao-motheo e rarahaneng ea 'mele le bothata bo phahameng ba botekgeniki ba MR Field, MR ea li-multi-core E bile sebaka se ikhethang sa lipatlisiso tsa litsi tse seng kae tse holimo tsa lipatlisiso tsa boenjiniere. Leha multicore MR E entse tsoelo-pele e kholo ka mor'a lilemo tse mashome tsa tsoelo-pele, ho ntse ho e-na le khaello ea boitsebiso bo lekaneng ba kliniki ho ntšetsa pele tšimo ena ho sebeletsa bakuli e le kannete.

Ho ipapisitsoe le boqapi bo phehellang tšimong ea MR, Philips o ile a qetella a robehile botlolo ea nts'etsopele ea MR ea mantlha 'me a lokolla sethala se secha sa lipatlisiso tsa bongaka se nang le li-nuclide tse ngata indastering. Sethala ke eona feela sistimi e nang le lits'ebetso tse ngata lefats'eng ho fumana setifikeiti sa EU Safety Conformity Certification (CE) le US Food and Drug Administration (FDA), e nolofalletsang tharollo ea MR e nang le mefuta e mengata ea mantlha: li-coil tse amohetsoeng ke FDA, tšireletso e felletseng ea tatelano, le kaho e tloaelehileng ea seteishene. Basebelisi ha ba hloke ho hlomelloa ka litsebi tsa fisiks tsa profeshenale tsa resonance, lienjineri tsa khoutu le baqapi ba RF gradient, e leng bonolo ho feta 1H spectroscopy/imaging ea setso. Eketsa phokotso ea lits'enyehelo tsa MR tse ngata tsa mantlha, phetoho ea mahala lipakeng tsa lipatlisiso tsa mahlale le mokhoa oa bongaka, ho khutlisa litšenyehelo ka potlako, e le hore MR oa mantlha a kene tleliniking.

Multi-core MR Hona joale ke tataiso e ka sehloohong ea "Leano la Ntlafatso ea Indasteri ea Lisebelisuoa tsa Bongaka ea Lilemo tse 14", 'me ke theknoloji ea mantlha ea ho nahana ka bongaka ho senya mokhoa oo le ho kopana le biomedicine e tsoetseng pele. Sehlopha sa bo-ramahlale ba Philips China, se susumetsoang ke ho ntlafatsa lipatlisiso tsa mahlale tsa bareki le bokhoni ba boqapi, se ile sa etsa lipatlisiso tse hlophisehileng mabapi le MR oa mefuta e mengata. Dr. Sun Peng, Dr. Wang Jiazheng et al. pele o ile a etsa tlhahiso ea khopolo ea MR-nucleomics ho NMR ho Biomedicine (top Journal of the First Region of Spectroscopy of Chinese Academy of Sciences), e ka sebelisang MR Thehiloe ho li-nuclide tse fapaneng ho boloka mefuta e sa tšoaneng ea mesebetsi ea lisele le mekhoa ea mafu. Kahoo, ho ka etsoa kahlolo e felletseng le tlhahlobo ea mafu le kalafo [1]. Khopolo ea MR Multinucleomics e tla ba tataiso ea kamoso ea MR Development. Pampiri ena ke tlhahlobo ea pele e hlophisitsoeng ea MR ea li-multi-core Lefatšeng, e koahelang motheo oa khopolo-taba ea MR ea mefuta e mengata, lipatlisiso tsa pele ho kliniki, phetoho ea meriana, nts'etsopele ea hardware, tsoelo-pele ea algorithm, mekhoa ea boenjiniere le likarolo tse ling (Setšoantšo sa 2). Ka nako e ts'oanang, sehlopha sa bo-ramahlale se ile sa sebelisana le Moprofesa Song Bin oa Sepetlele sa West China ho phethela sengoloa sa pele sa tlhahlobo mabapi le phetoho ea bongaka ea MR oa China, e hatisitsoeng koranteng ea Insights into Imaging [2]. Phatlalatso ea letoto la lingoloa tse mabapi le MR ea Multicore e Bontša hore Philips ehlile e tlisa moeli oa litšoantšo tsa limolek'hule tse ngata ho China, ho bareki ba Machaena le ho bakuli ba Machaena. Tumellanong le mohopolo oa mantlha oa "China, bakeng sa Chaena", Philips o tla sebelisa MR ea li-multi-core Ho ntšetsa pele nts'etsopele ea matla a khoheli a China le ho thusa sesosa sa China e phetseng hantle.

Multi-nuclear MRI ke theknoloji e hlahang. Ka nts'etsopele ea MR Software le hardware, MRI ea nyutlelie e mengata e sebelisitsoe ho lipatlisiso tsa motheo le tsa kliniki tsa phetolelo ea mekhoa ea batho. Monyetla oa eona o ikhethang ke hore e khona ho bonts'a ts'ebetso ea nako ea 'nete ea matla a metabolism lits'ebetsong tse fapaneng tsa pathological, ka hona e fana ka menyetla ea ho hlahlojoa kapele ha mafu, tlhahlobo ea katleho, ho etsa liqeto tsa kalafo le nts'etsopele ea lithethefatsi. E ka ba ea thusa ho hlahloba mekhoa e mecha ea pathogenesis.

E le ho khothaletsa tsoelo-pele e tsoelang pele ea tšimo ena, ho kenya letsoho ka mafolofolo ha litsebi tsa bongaka hoa hlokahala. Ntlafatso ea bongaka ea li-platform tsa li-multicore e bohlokoa, ho kenyeletsoa kaho ea lits'ebetso tsa mantlha, maemo a mahlale a mahlale, palo le maemo a liphetho, ho lekola liphuputso tse ncha, ho kopanngoa ha lintlha tse ngata tsa metabolic, joalo-joalo, ntle le nts'etsopele ea liteko tse lebelletsoeng ho feta tse ngata, e le ho ntšetsa pele phetoho ea bongaka ea MR Technology e tsoetseng pele. Re lumela ka tieo hore MR ea mefuta e mengata e tla fana ka sebaka se pharaletseng bakeng sa litsebi tsa litšoantšo le tsa bongaka ho etsa lipatlisiso tsa bongaka, 'me liphello tsa eona li tla thusa bakuli lefatšeng ka bophara.